How does Clomiphene work To Control Fertility?

 Clomiphene is used to induce ovulation (production of eggs) in women who have not produced eggs (eggs) but wish to become pregnant (infertile). Clomiphene belongs to a group of drugs known as ovulation-stimulating drugs. It works similarly to estrogen, a female hormone that causes eggs to develop and release in the ovaries.

·        How to use clomiphene citrate?

Clomiphene must be taken exactly as prescribed by your doctor to be most effective. The following procedures can be used to monitor induction cycles: Follicle monitoring by vaginal ultrasound, starting to 6 days after the last pill. Serial transvaginal ultrasound can reveal the size and number of developing cysts. It can also provide presumptive evidence of ovulation such as sudden collapse of the preovulatory follicle and increased fluid volume in the uterine sac. After ovulation, it may exhibit signs of lutealization such as loss of well-defined follicular margins and presence of internal echoes. Serum estradiol levels, starting -6 days after the last pill Increased urine LH concentration Test for LH elevation in urine 3- days after last dose of clomiphene Post-ovulation test 1-3 days before ovulation to check for at least 5 progressive sperms per HPF Mid-luteal progesterone, with at least 10 ng/ml 7-9 days after ovulation is considered sufficient. Clomiphene activates the pituitary gland in the brain to secrete increased amounts of follicle-stimulating hormone (FSH) and LH (luteal hormone). This action stimulates the growth of the follicle and thus the initiation of ovulation. During a normal menstrual cycle, only one egg is released.

Clomiphene is used to induce ovulation (production of eggs) in women who have not produced eggs (eggs) but wish to become pregnant (infertile). Clomiphene belongs to a group of drugs known as ovulation-stimulating drugs. It works similarly to estrogen, a female hormone that causes eggs to develop and release in the ovaries. Clomiphene citrate is an oral medication that induces ovulation by blocking estrogen receptors. This artificial anti-estrogen effect tricks your body into believing that estrogen levels are low, which stimulates the production of more follicle-stimulating hormone (FSH). Clomiphene improves the chances of pregnancy for most women who ovulate irregularly and with less risk of dangerous side effects. In addition to ovulation, clomiphene is also used along with intrauterine insemination to treat unexplained infertility. This medication is used to treat infertility in women.

 

·        How does Clomiphene work?

 It works by stimulating an increase in the amount of a hormone that aids in the development and release of a mature egg (ovulation). This medicine is not recommended for women whose ovaries are no longer producing eggs correctly (primary pituitary or ovarian failure). If three to six Clomid cycles do not result in pregnancy, new treatment options may be considered. Six cycles of Clomid is considered the upper limit, although some health care providers suggest continuing if pregnancy does not occur before the third cycle of treatment.

Clomiphene is used to induce ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent the natural process of ovulating. Side Effects Abdominal discomfort, bloating, abdominal/pelvic bloating, flushing ("hot flashes"), breast tenderness, headache, or dizziness may occur. If any of these effects persist or get worse, tell your doctor or pharmacist right away. Changes in vision (such as blurred, patchy, or flickering vision) can sometimes occur during treatment with clomiphene, especially if you are exposed to bright light. These side effects usually go away days or weeks after stopping treatment.

 

 

Enclomiphene citrate is effective in increasing serum testosterone levels in hypogonadal men, as well as maintaining sperm count. Enclomiphene is used to increase serum total testosterone levels while maintaining sperm counts within normal limits in men with secondary hypogonadism. Enclomiphene is a Selective Estrogen Receptor Modulator (SERM) for the treatment of female infertility.

 

It works by promoting the release of reproductive hormones. This helps stimulate ovulation from the ovaries (ovulation). Clomiphene citrate has been used off-label to increase luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) in men with secondary hypogonadism. A newer agent, enclomiphene citrate, is a trans isomer of clomiphene citrate and is being investigated for use in men with hypogonadism. Enclomiphene citrate is a potent and orally active estrogen receptor antagonist with antiestrogenic properties.